Sarah Mohamed Ellithy, Rabab Tawfik Mubarak And Dina B.E. Farag,

ABSTRACT
Background: Diabetes Mellitus Is The Most Common Metabolic Endocrine Disorder With Concomitant Oral Manifestation That Impact Dental Care. Ginger Is One Of The Most Commonly Consumed Dietary Condiments In The World. It?s Pharmacological And Physiological Actions Have Increased Over The Last Few Years. Objective: Investigate The Therapeutic Effect Of Aqueous Extract Of Zingiber Officinal On Submandibular Salivary Gland In Streptozotocin (STZ)-induced Diabetic Rats.

Materials and Methods: 24 Adult Male Albino Rats Were Utilized, Eight As Control Healthy Group (group I), Eight As STZ-induced Diabetic Group (group II) And Eight As Ginger (Zingiber Officinale) Treated Diabetic Group (group III). All The Animals In All Groups Were Sacrificed After 30 Days From The Beginning Of Ginger Extract Treatment. The Submandibular Salivary Glands Were Dissected And Examined Histologically, Immunohistochemically, And By Real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR).

Results: Histologically, Diabetic Untreated Group (group II) Showed Marked Loss Of Acinar Architecture As Well As Degeneration In Duct System. Group III, Revealed Almost Normal Acinar And Ductal Histology. Immunohistochemically, There Was As Significant Statistical Decrease In The Expression Of NF-KB In Group III As Compared To Group II. RT-PCR Analysis Demonstrated A Statistical Significant Decrease In IL-2 MRNA Gene Expression In Group III As Compared To Group II.

Conclusions: Diabetes Led To Marked Histopathological Changes In Rat?s Submandibular Salivary Glands. Zingiber Officinale (ginger) Administration Led To Beneficial Pharmacological Effect Mainly Through Its Antioxidant And Anti-inflammtory Effect.